Stem Cell Information
Stem Cell Therapy for Autism
What is Autism?
Autism is a spectrum of disorders characterized by marked abnormalities in communication and social interactions. Two common consistent findings are associated in children with this
disorder are diminished oxygenation in specific areas of the brain and a chronic immunologically mediated inflammatory condition in the gut.
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Current investigative therapies for autism attempt to reverse these abnormalities through administration of antibiotics, anti-inflammatory agents, and hyperbaric oxygen. Unfortunately, none of these approaches address the root causes of oxygen deprivation and
intestinal inflammation.
The rationale behind treating autism with umbilical cord tissue-derived mesenchymal stem
cells is that autism, and its degree of severity, has been significantly correlated inflammatory and neuro-inflammatory cytokines including macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC). Intravenous administration of umbilical cord MSCs has been shown in multiple clinical trials to decrease inflammation. Decreasing
inflammation in the autistic patient may alleviate symptoms of autism.
Through administration of mesenchymal stem cells, we have observed improvement in patients treated at our facilities.
Related Scientific Publications:
Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels
Elevated serum levels of macrophage-derived chemokine and thymus and activation- regulated chemokine in autistic children - Journal of Neuroinflammation
Stem Cell Therapy in Autism - Journal of Translational Medicine
Which types of stem cells are used to treat autism and how are they obtained?
The adult stem cells used to treat autism at the Stem Cell Institute come from human
umbilical cord tissue (allogeneic mesenchymal). Umbilical cords are donated by mothers after normal, healthy births. Before they are approved for treatment all umbilical cord-derived stem cells are screened for viruses and bacteria to International Blood Bank Standards.
Umbilical cord-derived stem cells are ideal for the treatment of autism because they allow our physicians to administer uniform doses and they do not require any stem cell collection from the patient, which for autistic children and their parents, can be an arduous process. Because they are collected right after (normal) birth, umbilical cord-derived cells are much more potent than their "older" counterparts like bone marrow-derived cells for instance. Cord tissue-derived mesenchymal stem cells pose no rejection risk because the body does not recognize them as foreign.
Stem Cell Institute
"Through retrospective analysis of our cases, we've identified proteins and genes that allow us to screen several hundred umbilical cord donations to find the ones that we know are most effective. We only use these cells and we call them "golden cells TM
What are the advantages of treating autism with allogeneic umbilical cord tissue-derived stem
cells?
Since HUCT mesenchymal stem cells are immune system privileged, cell rejection is not an issue and Human Leukocyte Antigen (HLA) matching is
not necessary.
The stem cells with the best anti-inflammatory activity, immune modulating
capacity, and ability to stimulate regeneration can be screened and selected.
Allogeneic stem cells can be administered multiple times over the course of
days in uniform dosages that contain high cell counts.
Umbilical cord tissue provides an abundant supply of mesenchymal stem cells.
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Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist.
Neil H Riordan PA, PhD, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future.
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Scientific Articles
Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism
Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels
Neil H. Riordan, Maria Luisa Hincapié, Isabela Morales, Giselle Fernandez, Nicole Allen, Cindy Leu, Marialaura Madrigal, Jorge Paz Rodriguez, Nelson Navarro
https://doi.org/10.1002/sctm.19-0010
Stem Cell Therapy for Autism
Ichim T, Solano F, Glenn E, Morales F, Smith L, Zabrecky G, Riordan Neil.
- Journal of Translational Medicine 2007, 5:30
The Stem Cell Institute, located in Panama City, Panama, is one of the leading adult stem cell research and treatment centers in the world. Lying at the crossroads of the North and South American continents, Panama is a very "Ameri- canized" country. It is a top destination for retirement and medical tourism with world-class medical technology and many U.S.-trained physicians.
The science originates from Medistem Inc., an American biotechnology company founded by Neil Riordan, PA, PhD. Together with leading universities, Dr. Riordan has published more than 70 articles in peer-reviewed scientific journals.
In addition to his scientific journal publications, Dr. Riordan has authored two books about mesenchymal stem cell thera- py: Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives and MSC (Mes- enchymal Stem Cells): Clinical Evidence Leading Medicine's Next Frontier. Dr. Riordan has also written two scientific book chapters on the use of non-controversial stem cells from placenta and umbilical cord.
At the Stem Cell Institute, their mission is to be at the forefront of research and development, using adult stem cell protocols for the treatment of chronic diseases and conditions.
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